Arvinas, Inc. is a clinical-stage biotechnology company focused on the discovery, development, and commercialization of therapies that degrade disease-causing proteins. It develops proteolysis targeting chimeras (PROTAC) targeted protein degraders designed to use the body's natural protein disposal system to remove disease-causing proteins. Its pipeline includes ARV-102 for neurodegenerative diseases such as Parkinson's disease and progressive supranuclear palsy, ARV-806 for cancers with the G12D mutation, ARV-393 for relapsed/refractory non-Hodgkin lymphoma, ARV-027 for a polyglutamine-expanded androgen receptor in skeletal muscle, and vepdegestrant for locally advanced or metastatic ER+/HER2- breast cancer. The company also develops Bavdegalutamide (ARV-110) and Luxdegalutamide (ARV-766) for metastatic castration-resistant prostate cancer, and has collaborations with Pfizer, Genentech, F. Hoffman-La Roche, Carrick Therapeutics, and Bayer. Founded in 2013, Arvinas is based in New Haven, Connecticut.